Centellian24
Dongguk Pharmaceutical's dermocosmetic brand built on 50+ years of centella asiatica research since 1968.
1 products analyzed on ana2me. Independent ingredient analysis — not affiliated with Centellian24.
Products (1)
- Madeca Cream Tight Lifting — A lifting cream built on fermented centella and 4,000 ppm madecassic acid — from Dongguk Pharmaceutical, Korea's centella authority since 1968.
Notable Ingredients
- Fermented Centella Extract — Fermentation by Lactobacillus breaks down centella's large triterpenoid molecules (asiaticoside, madecassoside) into smaller, more bioavailable forms. The ferment filtrate retains the soothing and wound-soothing properties of centella while improving skin penetration. Also produces postbiotic metabolites (lactic acid, peptides) that support the skin microbiome.
- Madecassic Acid (4,000 ppm) — Madecassic acid activates TGF-β signaling in fibroblasts, directly stimulating type I and III collagen production. At 4,000 ppm, this is a clinical-grade concentration — significantly higher than most centella creams that rely on whole-plant extract. Also suppresses MMP-1 (the enzyme that breaks collagen down), providing both offense and defense for skin firmness.
- Centella Stem Cell Extracellular Vesicles — Extracellular vesicles from centella asiatica callus (stem cell) culture carry bioactive cargo — proteins, lipids, and small RNAs — that can signal to human skin cells. They act as nano-scale delivery vehicles, fusing with keratinocyte membranes to deliver regenerative instructions. This is the same exosome technology trending in K-beauty clinics, adapted from plant cell culture.
- Niacinamide — Increases ceramide synthesis in the stratum corneum, strengthening the lipid barrier from within. Inhibits melanosome transfer from melanocytes to keratinocytes for brightening. At 2-5%, also regulates sebum production. Pairs well with the centella actives — niacinamide strengthens the barrier while centella repairs it.
- Retinol + 3-O-Ethyl Ascorbic Acid — Retinol converts to retinoic acid in the skin, accelerating cell turnover and stimulating collagen production. 3-O-ethyl ascorbic acid is one of the most stable vitamin C derivatives — it inhibits tyrosinase for brightening and scavenges free radicals. Together they address aging (retinol) and pigmentation (vitamin C) simultaneously, which is why this cream positions itself as a comprehensive anti-aging formula.
- Ectoin + Ceramide NP + Squalane — Ectoin is a stress-protection molecule from extremophile bacteria — it forms a hydration shell around skin cells, shielding them from UV, pollution, and desiccation. Ceramide NP fills gaps in the lamellar lipid bilayer for barrier repair. Squalane (hydrogenated squalene) mimics the skin's natural sebum to seal everything in. This trio protects the barrier while the potent actives (retinol, madecassic acid) do their work.